Thiopurine Methyltransferase (TPMT) Genotyping Test

Thiopurine Methyltransferase (TPMT) Genotyping Test

Category
Drug Monitoring
Sample
Urine sample — preferably first-morning, mid-stream, in a sterile container
Reports () Terms & Conditions Report time varies with time of sample collection.
In 12 days
Fasting
No Fasting
Age
5+ Years

What Is This Test?

A pharmacogenomic test that checks your TPMT gene variants, which affect how your body processes certain medicines.

Why this test is performed?

Helps your doctor predict your risk of serious side-effects from azathioprine and 6-mercaptopurine, so the right medicine and dose can be chosen. The result is valid for life.

Who should take this test?

People taking this medicine, to check the dose is safe and effective — as advised by the doctor.

Test Preparation

No fasting needed. Give a first-morning, mid-stream urine sample in a sterile container.

Medical disclaimer · for information only, not medical advice

This article is for general information and education only. It is not medical advice, does not create a doctor–patient relationship, and is not a substitute for consultation with a qualified doctor who has assessed your individual situation. Never delay seeking medical advice because of something you have read here.

In a medical emergency, call 112, or 108 for an ambulance where that service operates, or go to your nearest emergency department. If you are in mental health distress, Tele-MANAS is free and available 24×7 on 14416.

Read our Editorial Policy and Medical Review Process.

Frequently asked questions

No. Your genes do not change, so the result can be used for future prescriptions.

No fasting is needed. You can eat and drink normally unless your doctor has advised otherwise.

Urine sample — preferably first-morning, mid-stream, in a sterile container.

Usually within 10–11 days after the sample reaches the lab. You will receive the report online.

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