Osmotic Fragility Test

Osmotic Fragility Test

Category
Blood
Sample
Blood sample taken from a vein in your arm
Reports () Terms & Conditions Report time varies with time of sample collection.
In 5 days
Fasting
No Fasting
Age
5+ Years

What Is This Test?

Measures how easily red blood cells burst when placed in salt solutions of decreasing strength.

Why this test is performed?

Helps diagnose hereditary spherocytosis, in which red cells are abnormally fragile, and is sometimes used in thalassaemia screening.

Who should take this test?

Tiredness, weakness, pale skin, fever, frequent infections, easy bruising or bleeding; routine health check-ups.

Test Preparation

No fasting needed.

Medical disclaimer · for information only, not medical advice

This article is for general information and education only. It is not medical advice, does not create a doctor–patient relationship, and is not a substitute for consultation with a qualified doctor who has assessed your individual situation. Never delay seeking medical advice because of something you have read here.

In a medical emergency, call 112, or 108 for an ambulance where that service operates, or go to your nearest emergency department. If you are in mental health distress, Tele-MANAS is free and available 24×7 on 14416.

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Frequently asked questions

Red cells break more easily than normal, which can cause anaemia, jaundice and an enlarged spleen.

No fasting is needed. You can eat and drink normally unless your doctor has advised otherwise.

Blood sample taken from a vein in your arm.

Usually within 3–4 days after the sample reaches the lab. You will receive the report online.

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